ATRAMON INJECTION

Dosage – An initial Atracurium Besylate dose of 0.3mg to 0.6mg per kg (depending on the duration of full blocked required), given as an intravenous bolus injection is recommended. This will provide adequate relaxation for about 15 to 30 min.

Endotracheal intubation can usally be accomplished with in 90 to 120 seconds of the intravenous injection of 0.5mg to 0.6mg per kg, maximum neuromuscular blockade is generally achieved approximately 3 to 5 minutes after administration

Contraindications – Atracurium is contraindicated in patients known to have a hypersensitivity to it and in neonates. It advantage is that, it does not require any dosage adjustment in renal or hepatic disease as it spontaneously degrades in the plasma.

Special Precautions: Dehydration or Electrolyte Abnormalities

Situation in which Histamine release would be problematic

Fracture or Muscle spasm

Muscle spasm

Hyperthermia

Adverse Drug Reactions:

Bronchospasm
Hypotension, Tachycardia
Flushing, rash
Allergic reactions including ANAPHYLAXIS

Drug Interaction:

Intensity and duration of paralysis may be prolonged by pretreatment with Succinylcholine, general anesthesia (inhalation), aminoglycosides (vancomycin), tetracyclines, Polymyxin b, Colistin, Clindamycin, etc
Higher infusion rates may be required and duration of action may be shortened in patients receiving long term Carbamazepine or Phnytoin

Mechanism of Action: it is a non-depolarizing agent antagonize the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end plate, this antagonism is inhibited and neuromuscular block reversed by acetylcholinesterase inhibitors such as neostigmine, edrophonium and pyridostigmine

Presentation: Atramon is available in pack of 10m Vial

Atramon Injection